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Laboratory of Biomedical Physics

What is common in oncology and physics?

Physical energy processes take place in cancer cells, and they are made up of levers, discs, electrical particles, pumps, membranes and other electrical and molecular devices, described in physics. So, without a doubt, help of physicists is necessary in order to fight with cancer illnesses successfully, to diagnose cancer timely and accurately, and to treat it effectively without harm to the entire human organism.

Research areas

  • Steady state and time resolved spectroscopy of biologically active molecules, photodrugs, sensitizers, gold-nanoclusters and nanoparticles in aqueous solution, healthy and cancerous cells and experimental animals.
  • Pharmacokinetics, accumulation and distribution of sensitizers, photodrugs, nanoparticles in 2D and 3D structures of healthy, cancerous and stem cells, healthy and cancerous tissues by confocal microscopy, spectroscopy and flow cytometry.
  • The primary photophysical, photochemical processes, and nanotoxicity of biologically active molecules, anticancer drugs, sensitizers biomarkers, nanoparticles and nanoplatforms in vitro and in vivo.
  • Developing of the new multifunctional diagnostics methods and therapy of cancer by implementing nanotechnological solutions - toward theranostics.

Main projects

  1. Research of nanoparticles and heavy metal toxicity mechanisms on fish during ontogenesis (2016-2018, Head R. Rotomskis).
  2. Response of mesenchymal stem cells and cancerous stem cells to impact of nanoparticles (2014-2016, Head R. Rotomskis).
  3. Modelling of toxicity of nanomaterials (MODENA) TD1204 activities. (2014-2016, Head R. Rotomskis).
  4. The European upconversion network – from the design of photon-upconverting nanomaterials to biomedical applications (2014-2018, Head R. Rotomskis).

 


Publications

2018

  1. Rotomskis R, Jurgelienė Ž, Stankevičius M, Stankevičiūtė M, Kazlauskienė N, Jokšas K, Montvydienė D, Kulvietis V, Karabanovas V. Interaction of carboxylated CdSe/ZnS quantum dots with fish embryos: Towards understanding of nanoparticles toxicity. Sci Total Environ. 2018; Vol. 635: 1280-1291.  
      •  Cover image Science of The Total Environment
  2. Cibulskaite Z, Kazlauskiene N, Rotomskis RKulvietis V. Toxicity of cadmium-based quantum dots and cadmium to rainbow trout oncorhynchus mykiss (walbaum, 1792) in early development stages. Fresenius Environmental Bulletin. 2018; 27(1): 241-245

  3. Kišonas J, Venius J, Sevriukova O, Grybauskas M, Guogyte K, Burneckis A, Rotomskis R. Application of reflectance confocal microscopy for early diagnosis of radiation-induced acute dermatitis in radiosensitive patient: case study. Radiation Protection Dosimetry (2018), pp. 1–5 doi:10.1093/rpd/ncy135.

  4. Saulite L, Pleiko K, Popena I, Dapkute D, Rotomskis R, Riekstina U. Nanoparticle delivery to metastatic breast cancer cells by nanoengineered mesenchymal stem cells. Beilstein J. Nanotechnol. 2018, 9, 321–332.

    •  Journal Cover
  5. Jurgelėnė Ž, Kazlauskienė N, Montvydienė D, Kulvietis V, Rotomskis R, Jokšas K. Embryotoxicity of Quantum Dots in Rainbow Trout Oncorhynchus mykiss During the Hatching Period. Bulletin of Environmental Contamination and Toxicology (2018) 101:191–196. https://doi.org/10.1007/s00128-018-2367-8.

  6. Kristinaityte K, Zalewski T, Kempka M, Sakirzanovas S, Baziulyte-Paulaviciene D, Jurga S, Rotomskis R, Valeviciene NR. Spin–lattice relaxation and diffusion processes in aqueous solutions of gadolinium-based upconverting nanoparticles at different magnetic fields. Applied Magnetic Resonance. p 1–9. 1613-7507.

  7. Neverauskienė A, Maciusovič M, Burkanas M, Gricienė B, Petkevičius L, Zaleckas L, Tamošiūnas A, Venius J. Image based simulation of the low dose computed tomography images suggests 13 mAs 120 kV suitability for non-syndromic craniosynostosis diagnosis without iterative reconstruction algorithms. European Journal of Radiology. 2018; 105: 168-174.

  8. Jarockyte G, Dapkute D, Karabanovas V, Daugmaudis JV, Ivanauskas F, Rotomskis R. 3D cellular spheroids as tools for understanding carboxylated quantum dot behavior in tumors. Biochim Biophys Acta. 2018; 1862(4):914-923. doi: 10.1016/j.bbagen.2017.12.014.

      • Cover image Biochimica et Biophysica Acta (BBA) - General Subjects

2017

  1. Baziulyte-Paulaviciene D, Karabanovas VStasys MJarockyte GPoderys V, Sakirzanovas S, Rotomskis R. Synthesis and functionalization of NaGdF4:Yb,Er@NaGdF4 core–shell nanoparticles for possible application as multimodal contrast agents. Beilstein J. Nanotechnol. 2017; 8:1815–24. (IF=3,127)
  2. Dapkute DSteponkiene SBulotiene D, Saulite L, Riekstina U, Rotomskis R. Skin-derived mesenchymal stem cells as quantum dot vehicles to tumors. International Journal of Nanomedicine. 2017; 2017:12 8129–42. (IF=4,300)
  3. Jagminas A, Mikalauskaitė A, Karabanovas V, Vaičiūnienė J. Methionine-mediated synthesis of magnetic nanoparticles and functionalization with gold quantum dots for theranostic applications. Beilstein J. Nanotechnol. 2017, 8: 1734–41. (IF=3,127)
  4. Matulionyte M, Dapkute D, Budenaite L, Jarockyte G, Rotomskis R. Photoluminescent gold nanoclusters in cancer cells: cellular uptake, toxicity, and generation of reactive oxygen species. International Journal of Molecular Sciences. 2017; 18(2):378. (IF=3,226)
  5. Rimeika R, Ciplys D, Poderys VRotomskis R, Shurd M.S. Fast-response and low-loss surface acoustic wave humidity sensor based on bovine serum albumin-gold nanoclusters film. Sensors and Actuators B: Chemical. 2017; 239:352–7. (IF=5,401)
  6. Saulite L, Dapkute D, Pleiko K, Popena I, Steponkiene SRotomskis R, Riekstina U. Nano-engineered skin mesenchymal stem cells: potential vehicles for tumour-targeted quantum-dot delivery. Beilstein J. Nanotechnol. 2017, 8, 1218–30. (IF=3,127)
  7. Stankevicius V, Kuodyte K, Schveigert D, Bulotiene D, Paulauskas T, Daniunaite K, Suziedelis K. Gene and miRNA expression profiles of mouse Lewis lung carcinoma LLC1 cells following single or fractionated dose irradiation. Oncology Letters. 2017; 13(6):4190–200. (IF=1,390)
  8. Stankevicius VVasauskas GRynkeviciene RVenius JPasukoniene VAleknavicius ESuziedelis K. Microenvironment and Dose-Delivery-Dependent Response after Exposure to Ionizing Radiation in Human Colorectal Cancer Cell Lines. Radiat Res. 2017; 188(3):291–302. (IF=2,539)
  9. Zalgeviciene V, Kulvietis V, Bulotiene D, Zurauskas E, Laurinaviciene A, Skripka A, Rotomskis R. Quantum dots mediated embryotoxicity via placental damage. Reprod Toxicol. 2017; 73:222–31. (IF=2,341)

2016

  1. Ceponis T, Gaubas E, Venius J, Cicinas A, Callens F, Kusakovskij J, Vrielinck H, Mizohata K, Raisanen J, Tikkanen P. ESR spectroscopy of alanine impacted by high energy irradiations for wide range dosimetry. Lithuanian Journal of Physics. 2016; 56(1):49–54. (IF=0,574)
  2. Damalakiene L, Karabanovas V, Bagdonas S, Rotomskis R. Fluorescence-Lifetime Imaging Microscopy for Visualization of Quantum Dots' Endocytic Pathway. International journal of molecular sciences. 2016; 17(4): 473: 1–8. DOI: 10.3390/ijms17040473. (IF=3,257)
  3. Jarockyte G, Daugelaite E, Stasys M, Statkute U, Poderys V, Tseng TC, Hsu SH, Karabanovas V, Rotomskis R. Accumulation and toxicity of superparamagnetic iron oxide nanoparticles in cells and experimental animals. Int. J. Mol. Sci. 2016; 17(8), 1193:1–13. (IF=3,257)
  4. Poderys V, Matulionyte-Safine M, Rupsys D, Rotomskis R. Protein Stabilized Au Nanoclusters: Spectral Properties And Photostability. View Researcher ID and ORCID. Lithuanian Journal of Physics. 2016; 56(1):55–65. (IF=0,574)
  5. Stankevicius V, Vasauskas G, Bulotiene D, Butkyte S, Jarmalaite S, Rotomskis R, Suziedelis K. Gene and miRNA expression signature of Lewis lung carcinoma LLC1 cells in extracellular matrix enriched microenvironment. BMC Cancer. 2016; 16:789. DOI 10.1186/s12885-016-2825-9. (IF=3,265)
  6. Šlėktaitė A, Kubiliūtė R, Sabonis D, Rotomskis R. Relation between spectral and spatial properties of gold nanoclusters modified by the morpholine ligand. Chemija. 2016; 27(2):93–9. (IF=0,547)
  7. Usinskiene J, Ulyte A, Bjornerud A, Venius J, Katsaros VK, Rynkeviciene R, Letautiene S, Norkus D, Suziedelis K, Rocka S, Usinskas A, Aleknavicius E. Optimal differentiation of high- and low-grade glioma and metastasis: a meta-analysis of perfusion, diffusion, and spectroscopy metrics. Neuroradiology. 2016; 58(4):339–50. DOI: 10.1007/s00234-016-1642-9. (IF=2,274)
  8. Vaišnorienė I, Didžiapetrienė J, Žalgevičienė V, Laurinavičienė A, Vaišnoras T, Kulvietis V, Rotomskis R. Reflectance confocal microscopy (RCM) and melanocyte-specific immunostaining of histologic skin sections. J Am Acad Dermatol. 2016; 75(2):439–40. (IF=5,621)

2015

  1. Damalakiene L, Karabanovas V, Bagdonas S, Pupelis L, Valius M, Rotomskis R. Suppression of a Specific Intracellular Uptake Pathway by a Saturating Accumulation of Quantum Dots. Journal of Biomedical Nanotechnology. 2015; 11:841–53. (IF = 7,578)
  2. Matulionytė M, Marcinonytė R, Rotomskis R. Photoinduced spectral changes of photoluminescent gold nanoclusters. J Biomed Opt. 2015; 20(5):051018. (IF=2,752)
  3. Rudys R, Bagdonas S, Kirdaitė G, Papečkienė J, Rotomskis R. Multidimensional visualization of healthy and sensitized rabbit knee tissues by means of confocal microscopy. J Biomed Opt. 2015; 20(5):051035. (IF=2,752)
  4. Vaitkuvienė A, McDonald M, Vahidpour F, Noben JP, Sanen K, Ameloot M, Ratautaitė V, Kašėta V, Biziulevičienė G, Ramanavičienė A, Nesladek M, Ramanavičius A. Impact of differently modified nanocrystalline diamond on the growth of neuroblastoma cells. New Biotechnol. 2015; 32(1): 7–12. (IF=2,898)
  5. Vansevičiūtė R, Venius J, Žukovskaja O, Kanopienė D, Letautienė S, Rotomskis R. 5-aminolevulinic-acid-based fluorescence spectroscopy and conventional colposcopy for in vivo detection of cervical pre-malignancy. BMC Womens Health. 2015; 15:35. (IF=1,657)

2014

  1. Damalakiene L, Karabanovas V, Bagdonas S, Pupelis L, Valius M, Rotomskis R. Suppression of a specific intracellular uptake pathway by a saturating accumulation of quantum dots. J Biomed. Nanotechnol. 2014; 10:1–13. (IF=7,578)
  2. Kalnaitytė A, Bagdonas S, Rotomskis R. Effects of light and protein on photoluminescence stability of thiol-capped CdSe / ZnS quantum dots. Lithuanian Phys. 2014; 54(4): 256–65. (IF=0.424)
  3. Karabanovas V, Skripka A, Valanciunaite J, Kubiliute R, Poderys V, Rotomskis R. Formation of self-assembled quantum dot-chlorin e6 complex: influence of nanoparticles phospholipid coating. J Nanopart Res. 2014; 16(11):pii2724. (IF=2,278)
  4. Karabanovas V, Zitkus Z, Kuciauskas D, Rotomskis R, Valius M. Surface properties of quantum dots define their cellular endocytic routes, mitogenic stimulation and suppression of cell migration. J Biomed Nanotechnol. 2014; 10(5):775–86. (IF=7,578)
  5. Pašukonienė V, Mlynska A, Steponkienė S, Poderys V, Matulionytė M, Karabanovas V, Statkutė U, Purvinienė R, Krasko JA, Jagminas A, Kurtinaitienė M, Strioga M, Rotomskis R. Accumulation and biological effects of cobalt ferrite nanoparticles in human pancreatic and ovarian cancer cells. Medicina (Kaunas). 2014; 50(4):235–44. (IF=0,508)
  6. Steponkiene S, Valanciunaite J, Skripka A, Rotomskis R. Cellular uptake and photosensitizing properties of quantum dot-chlorin e6 complex: in vitro study. J Biomed Nanotechnol. 2014; 10(4):679–86. (IF=7,578)
  7. Vaišnosrienė I, Rotomskis R, Kulvietis V, Eidukevičius R, Žalgevičienė V, Laurinavičienė A, Venius J, Didžiapetrienė J. Nevomelanocytic atypia detection by in vivo reflectance confocal microscopy. Medicina (Kaunas). 2014; 50(4):209–15. (IF=0,508)
  8. Valanciunaite J, Klymchenko AS, Skripka A, Richert L, Steponkiene S, Streckyte G, Rotomskis R. A non-covalent complex of quantum dots and chlorine e6: efficient energy transfer and remarkable stability in living cells revealed by FLIM. RSC Advances. 2014;4: 52270–8. (IF=3,708)
  9. Vansevičiūtė R, Venius J, Letautienė S. 5-Aminolevulinic acid-based fluorescence diagnostics of cervical preinvasive changes. Medicina (Kaunas). 2014; 50(3):137–43. (IF=0,508)

2013

  1. Damalakiene L, Karabanovas V, Bagdonas S, Valius M, Rotomskis R. Intracellular distribution of nontargeted quantum dots after natural uptake and microinjection. Int J Nanomedicine. 2013; 8:555–68
  2. Karabanovas V, Zitkus Z, Kuciauskas D, Rotomskis R, Valius M. Surface properties of quantum dots define their cellular endocytotic routes, mitogenic stimulation and suppresion of cell migration. J Biomed Nanotechnol. 2013; 10(5):775–86
  3. Kubiliute R, Maximova KA, Lajevardipour A, Yong J, Hartley JS, Mohsin AS, ...., Rotomskis R, et al. (14 authors). Ultra-pure, water-dispersed Au nanoparticles produced by femtosecond laser ablation and fragmentation. Int J Nanomedicine. 2013; 8:2601–11
  4. Kulvietis V, Zurauskas E, Rotomskis R. Distribution of polyethylene glycol coated quantum dots in mice skin. Exp Dermatol. 2013; 22(2):157–9
  5. Rotomskis R, Valanciunaite J, Skripka A, Steponkiene S, Spogis G, Bagdonas S, Streckytė G. Complexes of functionalized quantum dots and chlorine e(6) in photodynamic therapy. Lith J Phys. 2013; 53(1):57–68
  6. Rudys R, Kirdaite G, Bagdonas S, Leonavicienė L, Bradunaite R, Streckytė G, Rotomskis R. Spectroscopic assessment of endogenous porphyrins in a rheumatoid arthritis rabbit model after the application of ALA and ALA-Me. J Photochem Photobiol B. 2013; 119:15–21
  7. Sabonis D, Dauderis G, Rotomskis R. The two photon absorbtion of quantum dots: experimental studies. Proceedings of the 11th International Conference „Medical Physics in the Baltic States“. Kaunas, Lietuva. Technologija. 2013; 11:19–23
  8. Skripka A, Valanciunaite J, Dauderis G, Poderys V, Kubiliute R, Rotomskis R. Two-photon excited Quantum dots as energy donors for photosensitizer chlorin e6. J Biomed Opt. 2013; 18(7):078002
  9. Vansevičiūtė R, Žukovskaja O, Venius J. Comparison of 5-aminolevulinic acid based fluorescence diagnostics with histology in the detection of cervical neoplasia. Proceedings of the 11th International Conference „Medical Physics in the Baltic States“. Kaunas, Lietuva. Technologija. 2013; 11:12–4
  10. Venius J, Zurauskas E, Rotomskis R. High resolution imaging of the human cardiac conduction system using reflectance confocal microscopy. Tohoku J Exp Med. 2013; 229(1):67–73

2012

  1. Lapienis J, Žalgevičienė V, Bagdonas S, Zakarevičius E, Žurauskas E, Graželienė G, Didžiapetrienė J, Rotomskis R. Microscopic evidence of placenta as a natural barrier for a photosensitizer. Vet Med Zoot. 2012; 60(82):39−44
  2. Žalgevičienė V, Kulvietis V, Bulotienė D, Didžiapetrienė J, Rotomskis R. The effect of nanoparticles in rats during critical periods of pregnancy. Medicina. 2012; 48(5):256−264



Updated 2019-02-28 14:49