Laboratory of Cancer Epidemiology

What is the role of cancer epidemiology in developing of health policy?

Cancer is an age-related disease - the incidence of most cancers increases with age, rising more rapidly beginning in midlife. As part of the epidemiological transition, cancer incidence is expected to increase in the future, further straining limited health care resources. Descriptive cancer epidemiology holds an important role in influencing policy and research initiatives, from both health systems and scientific perspectives. Appropriate allocation of resources for cancer prevention, early diagnosis, and curative and palliative care requires detailed knowledge of the local burden of cancer.

Research areas:

  • Descriptive studies based on Lithuanian Cancer Registry data (analysis of cancer incidence, mortality, survival);
  • Research to identify occupational, environmental, and other factors affecting cancer risk, characterize exposure-response relationships, identify susceptible populations;
  • Prevention and screening-based research (analysis of different aspects of screening interventions).

Main projects:

  1. Surveillance of mammographic screening and prostate cancer early detection programmes (2016-2020, Principal investigator: G. Smailytė).
  2. Impact of participation in screening programme on the risk of death from cervical cancer in Lithuania (2017-2019, Principal investigator: Rūta Everatt).
  3. Site-specific cancer risk and mortality risk in the cohort of Chernobyl cleanup workers (2017-2020, Principal investigator: G. Smailytė).




  1. Everatt R, Intaitė B. Trends in cervical cancer mortality rates in Lithuania, 1987–2016. Cancer Epidemiology. 2018; 57: 85-89.
  2. Janulionis E, Samerdokiene V, Valuckas KP, Atkocius V, Rivard MJ. Second primary malignancies after high-dose-rate 60Co photon or 252Cf neutron brachytherapy in conjunction with external-beam radiotherapy for endometrial cancer. Brachytherapy; 2018; 17(5): 768–774.
  3. Kaceniene A, Danila E, Cicenas S, Smailyte G. Suicide risk among lung cancer patients in Lithuania. Clin Respir J. 2018; 12(9): 2455-2456. doi: 10.1111/crj.12916.
  4. Kazlauskiene J, Kaceniene A, Smailyte G, Zagminas K, Navickas A, Bulotiene G. The risk factors for depression in Lithuanian breast cancer patients. Psycho-oncology. 2018; 27(10): 2508-2510. doi: 10.1002/pon.4820.
  5. Kuzmickiene I, Atkocius V, Aleknavicius E, Ostapenko V. Impact of season of diagnosis on mortality among breast cancer survivors. Journal of Cancer Research and Therapeutics 2018 V. 14(12) : 1091-1097.
  6. Poškus E, Jakaitienė A, Smailytė G, Strupas K, Kryžauskas M, Poškus T, Mikalauskas S, Samalavičius NE, Aliošin O, Dailidėnas Š, Tamelis A, Saladžinskas Ž, Lizdenis P. Improved perioperative care is associated with improved long-term survival in colorectal cancer. International journal of colorectal disease, 2018; 33(6):779-785. doi: 10.1007/s00384-018-3021-y
  7. Samalavicius NE, Dulskas A, Uselis S, Smolskas E, Smailyte G, Lunevicius R. High vascular ligation in left-sided colon cancer surgery is safe and adequate. European Surgery-Acta Chirurgica Austriaca. 2018; 50(5): 221-227. DOI: 10.1007/s10353-018-0542-0
  8. Urbonas V, Smailyte G. Combination of cytokine-directed and anti-programmed cell death protein 1 therapy - a new attractive option in melanoma treatment? Melanoma Res. 2018 Oct;28(5):469-470. doi: 10.1097/CMR.0000000000000470.


  1. Baltruskeviciene E, Kazbariene B, Aleknavicius E, Krikstaponiene A, Venceviciene L, Suziedelis K, Stratilatovas E, Didziapetriene J. Changes of reduced glutathione and glutathione S-transferase levels in colorectal cancer patients undergoing treatment. Tumori. 2017:0. (IF=1,233)
  2. Everatt R, Kuzmickiene I, Davidaviciene E, Cicenas S. Non-pulmonary cancer risk following tuberculosis: a nationwide retrospective cohort study in Lithuania. Infectious Agents and Cancer. 2017; 12:33: 1–7. (IF=1,422)
  3. Kaceniene A, Krilaviciute A, Matuiziene J, Bulotiene G, Smailyte G. Increasing suicide risk among cancer patients in Lithuania from 1993 to 2012: a cancer registry-based study. Eur J Cancer Prev, 2017;26:S197-S203. (IF=2,556)
  4. Kavaliauskaitė D, Stakišaitis D, Martinkutė J, Šlekienė L, Kazlauskas A, Balnytė I, Lesauskaitė V, Valančiūtė A. The Effect of Sodium Valproate on the Glioblastoma U87 Cell Line Tumor Development on the Chicken Embryo Chorioallantoic Membrane and on EZH2 and p53 Expression. BioMed Research International. 2017; 2017(6326053): 12. (IF=2,476)
  5. Kupčinskas J, Steponaitienė R, Langner C, Smailytė G, Skiecevičienė J, Kupčinskas L, Malfertheiner P, Link A. LINE-1 hypomethylation is not a common event in preneoplastic stages of gastric carcinogenesis. Scientific reports. 2017; 7(1);4828:1–10. (IF=4,259)
  6. Stakišaitis D, Mozūraitė R, Kavaliauskaitė D, Šlekienė L, Balnytė I, Juodžiukynienė N, Valančiūtė A. Sex-related differences of urethane and sodium valproate effects on Ki-67 expression in urethane‑induced lung tumors of mice. Experimental and Therapeutic Medicine. 2017; 13(6): 2741–50. (IF=1,261)
  7. Vincerževskienė I, Jasilionis D, Austys D, Stukas R, Kačėnienė A, Smailytė G. Education predicts cervical cancer survival: a Lithuanian cohort study. Eur J Public Health. 2017; 27(3):421–4. (IF=2,431)
  8. Zabuliene L, Jasilionis D, Miseikyte-Kaubriene E, Stukas R, Kaceniene A, Smailyte G. Parity and risk of thyroid cancer: a population-based study in Lithuania. Horm Cancer. 2017; 8(5-6):325–9. (IF=3,709)


  1. Baltruškevičienė E, Kazbarienė B, Badaras R, Bagdonaitė L, Krikštaponienė A, Zdanavičius L, Aleknavičius E, Didžiapetrienė J. Glutathione and glutathione S-transferase levels in patients with liver metastases of colorectal cancer and other hepatic disorders. Turk J Gastroenterol. 2016; 27(4):336–41. (IF=0,532)
  2. Barauskas G, Urbonas K, Smailyte G, Pranys D, Pundzius J, Gulbinas A. Preoperative endoscopic biliary drainage may negatively impact survival following pancreatoduodenectomy for ampullary cancer. Dig Surg. 2016; 33(6):462–469. DOI: 10.1159/000445777. (IF=1,728)
  3. Everatt R, Kuzmickiene I, Davidaviciene E, Cicenas S. Incidence of lung cancer among patients with tuberculosis: a nationwide cohort study in Lithuania. International Journal of Tuberculosis and Lung Disease. 2016; 20(6):757–63. DOI: 10.5588/ijtld.15.0783. (IF=2,148)
  4. Everatt R, Zolubiene E, Grassi MC. Smoking cessation practice among family doctors in Lithuania: a Survey. Clinica Terapeutica. 2016; 167(5):101–7. doi: 10.7417/CT.2016.1949. (IF=0,329)
  5. Krilaviciute A, Vincerzevskiene I, Smailyte G. Basal cell skin cancer and the risk of second primary cancers: a cancer registry-based study in Lithuania. Ann Epidemiol. 2016; 26(7):511–4. (IF=2,335)
  6. Kuzmickiene I, Atkocius V, Aleknavicius E, Ostapenko V. Impact of season of diagnosis on mortality among breast cancer survivors. Journal of Cancer Research and Therapeutics. 2016: 1–7. (IF=0,777)
  7. Radisauskas R, Kuzmickiene I, Milinaviciene E, Everatt R. Hypertension, serum lipids and cancer risk: A review of epidemiological evidence. Medicina-Lithuania. 2016; 52(2):89–98. DOI: 10.1016/j.medici.2016.03.002. (IF=0,609)
  8. Samalavicius NE, Dulskas A, Baltruskeviciene E, Smailyte G, Skuciene M, Mikelenaite R, Venslovaite R, Aleknavicius E, Samalavicius A, Lunevicius R. Asymptomatic primary tumour in incurable metastatic colorectal cancer: is there a role for surgical resection prior to systematic therapy or not? Videosurgery Miniinv 2016; 11 (4):1-9. (IF=0,920)
  9. Samalavicius NE, Dulskas A, Lasinskas M, Smailyte G. Validity and reliability of a Lithuanian version of low anterior resection syndrome score. Techniques in Coloproctology. 2016; 20(4):215–20. DOI: 10.1007/s10151-015-1424-0. (IF=2,320)
  10. Smailyte G, Jasilionis D, Vincerzevskiene I, Shkolnikov VM. Education, survival, and avoidable deaths in Lithuanian cancer patients, 2001-2009, Acta Oncologica. 2016; 55(7):859–64. DOI: 10.3109/0284186X.2016.1156739. (IF=3,730)
  11. Stakisaitis D, Lesauskait V, Girdauskaitė M, Janulionis E, Ulys A, Benetis R. Investigation of Vitamin D-Binding Protein Polymorphism Impact on Coronary Artery Disease and Relationship with Longevity: Own Data and a Review. International Journal of Endocrinology. 2016; 8347379:1–7. DOI: 10.1155/2016/8347379. (IF=2,376)
  12. Stanevičiūtė J, Urbonienė D, Valančiūtė A, Balnytė I, Vitkauskienė A, Grigalevičienė B, Stakišaitis D. The effect of dichloroacetate on male rat thymus and on thymocyte cell cycle. International Journal of Immunopathology and Pharmacology. 2016; 0394632016674019:1–5. (IF=1,470)
  13. Ulinskas K, Janulionis E, Valuckas KP, Samerdokiene V, Atkocius V, Rivard MJ. Long-term results for Stage IIIB cervical cancer patients receiving external beam radiotherapy combined with either HDR 252Cf or HDR 60Co intracavitary brachytherapy. Brachytherapy. 2016; 15(3):353–60. DOI: 10.1016/j.brachy.2016.02.004. (IF=2,088)


Updated 2019-03-25 13:32