What are distinctive features of modern molecular cancer researches?
The purpose of performing of molecular cancer researches of the previous era was to deepen the understanding of cancer development. At present the vast majority of molecular cancer researches is designed for development of more effective anti-cancer therapy strategies.
While performing modern researches, cancer researchers accumulate far more data, so the probability increases to obtain clinically significant results of the researches, the implementation of which in the Clinic is also significant.
Experimental and clinical studies are performed in the laboratory. Technologies of total researches are implemented, new generation sequencing technologies, modern modelling systems (infrastructure of cell cultivation in monolayer and spatial cultures) are applied, and experience of researches using patient biomaterials is accumulated.
- Search for molecular cancer markers for cancer diagnosis, prognosis, and individualization of treatment, is based on cancer biology knowledge.
- The objective is a better understanding of molecular processes occurring in cancer cells and in organisms of patients during anti-cancer therapies for development of strategies of more effective anti-cancer therapy.
- Indentification of cancer progression associated circulating miRNA for disease prognosis and evaluation of the effectivity of anticancer therapy (2015-2018, Head Prof. N. E. Samalavičius).
- Development of the molecular tool for determination of thyroid follicular carcinoma. (2017-2019, Head Dr. K. Sužiedėlis).
- Assessment of brain tumors prognostic factors and early response to treatment by imaging biomarkers (2014-2017, Head Dr. E.Aleknavičius).
- Usinskiene, J., Ulyte, A., Bjørnerud, A., Venius, J., Vasileios, K., Katsaros, Rynkeviciene, R., Letautiene, S., Norkus, D., Suziedelis, K., Rocka, S., Usinskas, A. and Aleknavicius, E. “Erratum to: Optimal differentiation of high- and lowgrade glioma and metastasis: a meta-analysis of perfusion, diffusion, and spectroscopy metrics.” Neuroradiology 58.7 (2016): 741.
- Stankevicius, V., Vasauskas, G., Bulotiene, D., Butkyte, S., Jarmalaite, S., Rotomskis, R. and Suziedelis, K. “Gene and miRNA expression signature of Lewis lung carcinoma LLC1 cells in extracellular matrix enriched microenvironment.” BMC Cancer 16.1 (2016): n. pag.
- Stankevicius, V., Vasauskas, G., Rynkeviciene, R., Venius, J., Pasukoniene, V., Aleknavicius, E., Suziedelis, K. “Microenvironment and dose-delivery-dependent response after exposure to ionizing radiation in human colorectal cancer cell lines.” Biochemical and Biophysical Research Communications. 18;484.4 (2017):726-733.
Updated 2018-04-26 13:07