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Laboratory of Molecular Oncology

What are distinctive features of modern molecular cancer researches?

The purpose of performing of molecular cancer researches of the previous era was to deepen the understanding of cancer development. At present the vast majority of molecular cancer researches is designed for development of more effective anti-cancer therapy strategies.

While performing modern researches, cancer researchers accumulate far more data, so the probability increases to obtain clinically significant results of the researches, the implementation of which in the Clinic is also significant.

Experimental and clinical studies are performed in the laboratory. Technologies of total researches are implemented, new generation sequencing technologies, modern modelling systems (infrastructure of cell cultivation in monolayer and spatial cultures) are applied, and experience of researches using patient biomaterials is accumulated.

Research areas:

  1. Search for molecular cancer markers for cancer diagnosis, prognosis, and individualization of treatment, is based on cancer biology knowledge.
  2. The objective is a better understanding of molecular processes occurring in cancer cells and in organisms of patients during anti-cancer therapies for development of strategies of more effective anti-cancer therapy.

Main projects:

  1. Indentification of cancer progression associated circulating miRNA for disease prognosis and evaluation of the effectivity of anticancer therapy (2015-2018, Head Prof. N. E. Samalavičius).
  2. Development of the molecular tool for determination of thyroid follicular carcinoma. (2017-2019, Head Dr. K. Sužiedėlis).
  3. Assessment of brain tumors prognostic factors and early response to treatment by imaging biomarkers (2014-2017, Head Dr. E.Aleknavičius).

 


Publications:

2018

  1. Stakišaitis D, Juknevičienė M, Ulys A, Žaliūnienė D, Stanislovaitienė D, Šepetienė R, Slavinska A, Sužiedėlis K, Lesauskaitė V. ABO blood group polymorphism has an impact on prostate, kidney and bladder cancer in association with longevity. Oncology letters. 2018; 16(1): 1321-1331. DOI:10.3892/ol.2018.8749 (IF=1,664)
  2. Stakišaitis D, Zamarytė-Sakavičienė K, Lesauskaitė V, Jankūnas RJ. Off-label use of antipsychotic agents in dementia: evidence for the revision of the reimbursement policy. Ther Innov Regul Sci. 2018; 2168479018795857: 1-5. doi: 10.1177/2168479018795857 (IF=0,882)
  3. Stanevičiūtė J, Juknevičienė M, Palubinskienė J, Balnytė I, Valančiūtė A, Vosyliūtė R, Sužiedėlis K, Lesauskaitė V, Stakišaitis D. Sodium Dichloroacetate Pharmacological Effect as Related to Na–K–2Cl Cotransporter Inhibition in Rats. Dose-Response: An International Journal. 2018; Volume: 16 issue: 4: 1-11. https://doi.org/10.1177/1559325818811522. (IF=2,435)
  4. Strainiene E, Binkis M, Urnikyte S, Stankevicius V, Sasnauskiene A, Kundrotas G, Kazlauskas A, Suziedelis K. Microenvironment dependent gene expression signatures in reprogrammed human colon normal and cancer cell lines. BMC Cancer. 2018 Feb 27;18(1):222. doi: 10.1186/s12885-018-4145-8. (IF=3,288)
  5. Skeberdytė A, Sarapinienė I, Aleksander-Krasko J, Stankevičius V, Sužiedėlis K, Jarmalaitė S. Dichloroacetate and salinomycin exert a synergistic cytotoxic effect in colorectal cancer cell lines. Scientific Reports. 2018; 8(17744):1-13. DOI:10.1038/s41598-018-35815-4. (IF=4,122)
  6. Šlekienė L, Stakišaitis D, Balnytė I, Valančiūtė A. Sodium valproate inhibits small cell lung cancer tumor growth on the chicken embryo chorioallantoic membrane and reduces the p53 and EZH2 expression. Dose-Response. 2018; 16(2):1559325818772486. (IF=2,435)

2017

  1. Baltruskeviciene E, Kazbariene B, Aleknavicius E, Krikstaponiene A, Venceviciene L, Suziedelis K, Stratilatovas E, Didziapetriene J. Changes of reduced glutathione and glutathione S-transferase levels in colorectal cancer patients undergoing treatment. Tumori. 2017:0. (IF=1,233)
  2. Baltruskeviciene E, Schveigert D, Stankevicius V, Mickys U, Zvirblis T, Bublevic J, Suziedelis K, Aleknavicius E. Down-regulation of miRNA-148a and miRNA-625-3p in colorectal cancer is associated with tumor budding. BMC Cancer. 2017; 17(1):607. (IF=3,288)
  3. Cicenas J, Tamosaitis L, KvederaviciuteK, Tarvydas R, Staniute G, Kalyan K, Meskinyte-Kausiliene E, Stankevicius V, Valius M. KRAS, NRAS and BRAF mutations in colorectal cancer and melanoma. Medical Oncology. 2017; 34(2):26. (IF=2,634)
  4. Stankevicius V, Kunigenas L, Stankunas E, Kuodyte K, Strainiene E, Cicenas J, Samalavicius NE, Suziedelis K. The expression of cancer stem cell markers in human colorectal carcinoma cells in a microenvironment dependent manner. Biochem Biophys Res Commun. 2017; 484(4):726–33. (IF=2,466)
  5. Stankevicius V, Kuodyte K, Schveigert D, Bulotiene D, Paulauskas T, Daniunaite K, Suziedelis K. Gene and miRNA expression profiles of mouse Lewis lung carcinoma LLC1 cells following single or fractionated dose irradiation. Oncology Letters. 2017; 13(6):4190–200. (IF=1,390)
  6. Stankevicius V, Vasauskas G, Rynkeviciene R, Venius J, Pasukoniene V, Aleknavicius E, Suziedelis K. Microenvironment and Dose-Delivery-Dependent Response after Exposure to Ionizing Radiation in Human Colorectal Cancer Cell Lines. Radiat Res. 2017; 188(3):291–302. (IF=2,539)

2016

  1. Usinskiene, J., Ulyte, A., Bjørnerud, A., Venius, J., Vasileios, K., Katsaros, Rynkeviciene, R., Letautiene, S., Norkus, D., Suziedelis, K., Rocka, S., Usinskas, A. and Aleknavicius, E. “Erratum to: Optimal differentiation of high- and lowgrade glioma and metastasis: a meta-analysis of perfusion, diffusion, and spectroscopy metrics.” Neuroradiology 58.7 (2016): 741.
  2. Stankevicius, V., Vasauskas, G., Bulotiene, D., Butkyte, S., Jarmalaite, S., Rotomskis, R. and Suziedelis, K. “Gene and miRNA expression signature of Lewis lung carcinoma LLC1 cells in extracellular matrix enriched microenvironment.” BMC Cancer 16.1 (2016): n. pag.
  3. Stankevicius, V., Vasauskas, G., Rynkeviciene, R., Venius, J., Pasukoniene, V., Aleknavicius, E., Suziedelis, K. “Microenvironment and dose-delivery-dependent response after exposure to ionizing radiation in human colorectal cancer cell lines.” Biochemical and Biophysical Research Communications. 18;484.4 (2017):726-733.



Updated 2019-03-25 13:31