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Laboratory of Immunology

Immunology research news, future?

Scientific progress in the area of immunology and immunotherapy provides more and more opportunities to use the knowledge for treatment of cancer. We have worked for many years in this area, and we are the only group of cancer immunology scientists in Lithuania having the best qualified specialists. We become more relevant to cancer patients and the doctors that treat them.

Research areas:

  • Cancer Immunology:
    • Immunomonitoring of cancer patients.
    • Determination of immune biomarkers and prediction of anti-cancer treatment effectiveness.
    • Researches of immunogenicity and resistance of the tumor microenvironment.
  • Cancer immunotherapy:
    • Research of anti-cancer immunotherapy possibilities.
    • Researches of prognostic and predictive molecular markers with immunotherapy autologous dendritic cell vaccines.
  • Cell technologies:
    • Researches of increasing of the efficiency of dendritic cell vaccines.
    • Development and researches of anticancer vaccines.

Main projects:

  1. Immunomodulating properties of bacteriophage-derived dsRNA of different size and their use as vaccine adjuvants (2016-2018, Head V. Pašukonienė).
  2. We participate in the project “New prodrug activation systems for cancer genotherapies” of the national program “Healthy Aging” as partners.. (2015-2018, Head J. Urbonavičius, Vilnius University).
  3. Advanced therapies medical preparations, modulating the immune system, for treatment of cancer. (2017 -2019, Head V. Pašukonienė).
  4. Research of anti-cancer effectiveness of dendritic cells differentiated in vitro and matured using tumor destruction products in vivo in the models of experimental animals. (2017 -2021, Head V. Pašukonienė).

Publications:
2018
  1. Dobrovolskienė N, Pašukonienė V, Darinskas A, Kraśko JA, Žilionytė K, Mlynska A, Gudlevičienė Ž, Mišeikytė-Kaubrienė E, Schijns V, Lubitz W, Kudela P, Strioga M. Tumor lysate-loaded Bacterial Ghosts as a tool for optimized production of therapeutic dendritic cell-based cancer vaccines. Vaccine. 2018; 36(29):4171-4180. doi: 10.1016/j.vaccine.2018.06.016.
  2. Kraśko JA, Žilionytė K, Darinskas A, Dobrovolskienė N, Mlynska A, Riabceva S, Zalutsky I, Derevyanko M, Kulchitsky V, Karaman O, Fedosova N, Symchych TV, Didenko G, Chekhun V, Strioga M, Pašukonienė V. Post-operative unadjuvanted therapeutic xenovaccination with chicken whole embryo vaccine suppresses distant micrometastases and prolongs survival in a murine Lewis lung carcinoma model. Oncol Lett. 2018 Apr;15(4):5098-5104. doi: 10.3892/ol.2018.7950.
  3. Mlynska A, Povilaityte E, Zemleckaite I, Zilionyte K, Strioga M, Krasko J, Dobrovolskiene N, Peng MW, Intaite B, Pasukoniene V. Platinum sensitivity of ovarian cancer cells does not influence their ability to induce M2-type macrophage polarization. American Journal Of Reproductive Immunology. 2018; 80(3): e12996. DOI: 10.1111/aji.12996
  4. Skeberdytė A, Sarapinienė I, Aleksander-Krasko J, Stankevičius V, Sužiedėlis K, Jarmalaitė S. Dichloroacetate and salinomycin exert a synergistic cytotoxic effect in colorectal cancer cell lines. Scientific Reports. 2018; 8(17744):1-13. DOI:10.1038/s41598-018-35815-4. 
2017
  1. Darinskas A, Paškevičius M, Apanavičius G, Vilkevičius GL, Labanauskas L, Ichim TE, Rimdeika R. Stromal vascular fraction cells for the treatment of critical limb ischemia: a pilot study. Journal of translational medicine. 2017; 15(1);143:1–7. 
  2. Krasko JA, Zilionyte K, Darinskas A, Strioga M, Rjabceva S, Zalutsky I, Derevyanko M, Kulchitsky V, Lubitz W, KudelaP, Miseikyte-Kaubriene E, Karaman O, Didenko H, Potebnya H, Chekhun V, Pasukoniene V. Bacterial ghosts as adjuvants in syngeneic tumour cell lysate-based anticancer vaccination in a murine lung carcinoma model. Oncol Rep. 2017; 37(1):171–8.
  3. Michalek J, Hezova R, Turanek-Knotigova P, Gabkova J, Strioga M, Lubitz W, Kudela P. Oncolysate-loaded Escherichia coli bacterial ghosts enhance the stimulatory capacity of human dendritic cells. Cancer Immunology Immunotherapy. 2017; 66(2):149–59.
  4. Noreikaitė A, Antanavičiūtė I, Mikalayeva V, Darinskas A, Tamulevičius T, Adomavičiūtė E, Šimatonis L, Akramienė D, Stankevičius E. Scaffold design for artificial tissue with bone marrow stem cells. Medicina. 2017; 53(3):203–10.
  5. Stankevicius V, Vasauskas G, Rynkeviciene R, Venius J, Pasukoniene V, Aleknavicius E, Suziedelis K. Microenvironment and Dose-Delivery-Dependent Response after Exposure to Ionizing Radiation in Human Colorectal Cancer Cell Lines. Radiat Res. 2017; 188(3):291–302.

2016

  1. Kundrotas G, Gasperskaja E, Slapsyte G, Gudleviciene Z, Krasko J, Stumbryte A, Liudkeviciene R. Identity, proliferation capacity, genomic stability and novel senescence markers of mesenchymal stem cells isolated from low volume of human bone marrow. Oncotarget. 2016; 7(10):10788-802. doi: 10.18632/oncotarget.7456.
  2. Michalek J, Hezova R, Turanek-Knötigova P, Gabkova J, Strioga M, Lubitz W, Kudela P. Oncolysate-loaded Escherichia coli bacterial ghosts enhance the stimulatory capacity of human dendritic cells. Cancer Immunology, Immunotherapy. 2016; 1-11.
  3. Noreikaite A, Antanaviciute I, Mikalayeva V, Darinskas A, Tamulevicius T, Adomaviciute E, Šimatonis L, Akramiene D, Stankevicius E. Scaffold design for artificial tissue with bone marrow stem cells. Medicina (Kaunas). 2016; 52(5):335–342.



Updated 2019-03-25 13:33