Why does NCI need biobank?

Biobank consists of libraries of new generation, in which biomedical samples and health information of patients that were treated in NCI, are collected, stored and processed. We will accumulate large, well-classified collections of biological samples and health information of oncological patients, and researchers of the new generation will be able to use them, to search, find and receive information, intended for them for performing of high-level scientific researches.

Research areas

  • Creation, mastering and transfer for clinical practice of new freezing technologies (cryobiology researches, cell and tissue freezing technologies).
  • The search for molecular and genetic cancer markers (gene polymorphisms, gene expression tests in tumors of various localities), researches of carcinogenesis signalling paths.

  1. Significance of polymorphism of oncogenetic human papillomaviruses types and some genes, causing tumor process in carcinogenesis (2014-2018, Head Ž. Gudlevičienė).
  2. Significance of polymorphism of oncogenic types of human papillomaviruses and genes, influencing some tumor processes to efficiency of oncological patient therapy (2013–2017, Heads Ž. Gudlevičienė, A. Stumbrytė).
  3. Reducing of the gap between Europe and Africa in the area of bio-banking and biomedical researches (2015–2018, Head Ž. Gudlevičienė).


  1. Mozuraitiene JGudleviciene Z, Vincerzevskiene I, Laurinaviciene A, Pamedys J. Expression levels of FBXW7 and MDM2 E3 ubiquitin ligases and their c-MYC and p53 substrates in patients with dysplastic nevi or melanoma. Oncol Lett. 2021; 21(1):37. doi: 10.3892/ol.2020.12298. (IF=2,311)
  2. Daugelaviciene N, Grigaitis P, Gasiule L, Dabkeviciene D, Neniskyte U, Sasnauskiene A. Lysosome-targeted photodynamic treatment induces primary keratinocyte differentiation. J Photochem Photobiol B. 2021; 218:112183:1-12. doi: 10.1016/j.jphotobiol.2021.112183. PMID: 33831753 (IF=4,383)


  1. Stumbrytė-Kaminskienė A, Gudlevičienė Ž, Dabkevičienė D, Mackevičienė I. Combined Effect of HPV and Several Gene SNPs in Laryngeal Cancer. Medicina (Kaunas). 2020; 56(2):9-12. doi: 10.3390/medicina56020081. (IF=1,205)
  2. Gudlevičienė Ž, Žilinskas K, Kundrotas G, Grubliauskaitė M, BaltriukienėM, Bukelskienė V. Slow-Freezing Cryopreservation Ensures High Ovarian Tissue Quality Followed by In Vivo and In Vitro Methods and Is Safe for Fertility Preservation. Medicina. 2020; 56(10),547:1-17.  doi: 10.3390/medicina56100547. (IF=1,205)
  3. Sadzevičienė I, Liaugaudienė O, Besusparis J, Asadauskienė J, Kulikienė I, Brasiūnienė B, Sabaliauskaitė R, Jarmalaitė S. Recurrent Germline BRCA2 Gene Mutation in Lithuanian Family. Medicina 2020, 56(3), 119:1-9; doi: 10.3390/medicina56030119 (IF=1,205)
  4. Loriot Y, Sternberg CN, Castellano D, Oosting SF, Dumez H, Huddart R, Vianna K, Alonso Gordoa T, Skoneczna I, Fay AP, Nolè F, Massari F, Brasiuniene B, Maroto P, Fear S, Di Nucci F, de Ducla S, Choy E. Safety and efficacy of atezolizumab in patients with autoimmune disease: Subgroup analysis of the SAUL study in locally advanced/metastatic urinary tract carcinoma. Eur J Cancer. 2020; 138:202-211. doi: 10.1016/j.ejca.2020.07.023 (IF=7,275)
  5. Janavicius M, Lachej N, Anglickiene G, Vincerzevskiene I, Brasiuniene B. Outcomes of Treatment for Melanoma Brain Metastases. Journal of Skin Cancer. 2020; ID 7520924: 1-10. doi: 10.1155/2020/7520924 (Web of Science Master Journal List)


  1. Kundrotas G, Karabanovas V, Pleckaitis M, Juraleviciute M, Steponkiene S, Gudleviciene Z, Rotomskis R. Uptake and distribution of carboxylated quantum dots in human mesenchymal stem cells: cell growing density matters. J Nanobiotechnology. 2019 Mar 13;17(1):39. doi: 10.1186/s12951-019-0470-6. (IF=5,345)

  2. Jeršovienė V, Gudlevičienė Ž, Rimienė J, Butkauskas D. Human Papillomavirus and Infertility. Medicina (Kaunas). 2019 Jul 15;55(7). doi: 10.3390/medicina55070377. (IF=1,467)


  1. Dobrovolskienė N, Pašukonienė V, Darinskas A, Kraśko JA, Žilionytė K, Mlynska A, Gudlevičienė Ž, Mišeikytė-Kaubrienė E, Schijns V, Lubitz W, Kudela P, Strioga M. Tumor lysate-loaded Bacterial Ghosts as a tool for optimized production of therapeutic dendritic cell-based cancer vaccines. Vaccine. 2018; 36(29):4171-4180. doi: 10.1016/j.vaccine.2018.06.016. (IF=3,269)
  2. Baltruskeviciene E, Kazbariene B, Aleknavicius E, Krikstaponiene A, Venceviciene L, Suziedelis K, Stratilatovas E, Didziapetriene J. Changes of reduced glutathione and glutathione S-transferase levels in colorectal cancer patients undergoing treatment. Tumori. 2018 Oct;104(5):375-380. doi: 10.5301/tj.5000674. (IF=1,234)


  1. Baltruškevičienė E, Kazbarienė B, Badaras R, Bagdonaitė L, Krikštaponienė A, Zdanavičius L, Aleknavičius E, Didžiapetrienė J. Glutathione and glutathione S-transferase levels in patients with liver metastases of colorectal cancer and other hepatic disorders. Turk J Gastroenterol. 2016 Jul;27(4):336-41. doi: 10.5152/tjg.2016.15457. (IF=0,932)

  2. Kundrotas G, Gasperskaja E, Slapsyte G, Gudleviciene Z, Krasko J, Stumbryte A, Liudkeviciene R. Identity, proliferation capacity, genomic stability and novel senescence markers of mesenchymal stem cells isolated from low volume of human bone marrow. Oncotarget. 2016; 7(10):10788-802. doi: 10.18632/oncotarget.7456. (IF=5,168)


  1. Gudleviciene Z, Kanopiene D, Stumbryte A, Bausyte R, Kirvelaitis E, Simanaviciene V, Zvirbliene A. Studies on the integration of human papillomavirus type 16 in cervical cancer cells. Open Med (Wars). 2015; 10(1): 1–7. doi: 10.1515/med-2015-0001. (IF=1,50)

  2. Gudleviciene Z, Kundrotas G, Liudkeviciene R, Rascon J, Jurga M. Quick and effective method of bone marrow mesenchymal stem cell extraction. Open Med (Wars). 2014 Oct 8;10(1):44-49. doi: 10.1515/med-2015-0008. (IF=1,50)

  3. Simanaviciene V, Popendikyte V, Gudleviciene Z, Zvirbliene A. Different DNA methylation pattern of HPV16, HPV18 and HPV51 genomes in asymptomatic HPV infection as compared to cervical neoplasia. Virology. 2015 Oct;484:227-33. doi: 10.1016/j.virol.2015.06.008. (IF=2,362)

  4. Gudlevičienė Ž, Stumbrytė A, Juknė G, Simanavičienė V, Žvirblienė A. Distribution of human papillomavirus type 16 variants in Lithuanian women with cervical cancer. Medicina (Kaunas). 2015;51(6):328-35. doi: 10.1016/j.medici.2015.11.005. (IF=0,609)

  5. Bielskienė K, Bagdonienė L, Mozūraitienė J, Kazbarienė B, Janulionis E. E3 ubiquitin ligases as drug targets and prognostic biomarkers in melanoma. Medicina (Kaunas) 2015; 51(1): 1-9. doi: 10.1016/j.medici.2015.01.007. (IF=0,609)

  6. Mozūraitienė J, Bielskienė K, Atkočius V, Labeikytė D. Molecular alterations in signal pathways of melanoma and new personalized treatment strategies: Targeting of Notch. Medicina (Kaunas) 2015; 51(3): 133-145. doi: 10.1016/j.medici.2015.06.002. (IF=0,609)

  7. Simanaviciene V, Gudleviciene Z, Popendikyte V, Dekaminaviciute D, Stumbryte A, Rubinaite V, Zvirbliene A. Studies on the prevalence of oncogenic HPV types among Lithuanian women with cervical pathology. J Med Virol. 2015 Mar;87(3):461-71. doi: 10.1002/jmv.24073. (IF=1,998)


  1. Gudleviciene Z, Kanopiene D, Smailyte G, Didziapetriene J, Smolyakova R, Gutkovskaya E, Zukovec A, Kostevich G. Differences on the prevalence of human papillomavirus between Lithuania and Belarus. Centr Eur J Med 2014; 9(2): 285-291. DOI: 10.2478/s11536-013-0192-3. (IF=0,153)

  2. Gudleviciene Z, Didziapetriene J, Mackeviciene I, Cicenas S, Smolyakova R, Zhukavetc A. Prevalence of human papillomaviruses in patients with head and neck squamous cell carcinoma in Lithuania and Belarus. J Med Virol 2014; 86(3): 531-5. Erratum in: J Med Virol. 2014 Jul; 86(7): 1279. doi: 10.1002/jmv.23750. (IF=2,347)

  3. Dekaminaviciute D, Kairys V, Zilnyte M, Petrikaite V, Jogaite V, Matuliene J, Gudleviciene Z, Vullo D, Supuran C, Zvirbliene A. Monoclonal antibodies raised against 167-180 aa sequence of human carbonic anhydrase XII inhibit its enzymatic activity. J Enzyme Inhib Med Chem. 2014 Dec;29(6):804-10. doi: 10.3109/14756366.2013.856424. (IF=2,332)

  4. Mendy M, Caboux E, Sylla BS, Dillner J, Chinquee J, Wild C; BCNet survey participants. Infrastructure and facilities for human biobanking in low- and middle-income countries: a situation analysis. Pathobiology. 2014; 81(5-6): 252-60. doi: 10.1159/000362093. (IF=2,480)


  1. Ferraretti AP, Goossens V, Kupka M, Bhattacharya S, de Mouzon J, Castilla JA, Erb K, Korsak V, Nyboe Andersen A; European IVF-Monitoring (EIM) Consortium for the European Society of Human Reproduction and Embryology (ESHRE). Assisted reproductive technology in Europe, 2009: results generated from European registers by ESHRE. Hum Reprod. 2013;28(9): 2318-31. doi: 10.1093/humrep/det278. (IF=4,585)

  2. Schveigert D, Cicenas S, Bruzas S, Samalavicius NE, Gudleviciene Z, Didziapetriene J. The value of MMP-9 for breast and non-small cell lung cancer patients’ survival. Adv Med Sci. 2013;58(1):73-82. doi: 10.2478/v10039-012-0066-y. (IF=0,964)

  3. Schveigert D, Valuckas KP, Kovalcis V, Ulys A, Chvatovic G, Didziapetriene J. Significance of MMP-9 expression and MMP-9 polymorphism in prostate cancer. Tumori. 2013 Jul-Aug;99(4):523-9. doi: 10.1700/1361.15105. (IF=1,090)


  1. Gudleviciene Z, Smailyte G. Survival of patients with head and neck squamous cell carcinoma in association with human papillomavirus and p53 polymorphism. Centr Eur J Med 2012;7(3): 349-353. DOI: 10.2478/s11536-011-0148-4. (IF=0,262)

  2. Simanaviciene V, Popendikyte V, Gudleviciene Z, Armalyte S, Kirkutyte A, Shikova E, Zvirbliene A. Studies on the expression of p16INK4A mRNA in cervical dysplasias. Biotechnology & Biotechnological Equipment, 26:sup1, 80-84. DOI: 10.5504/50YRTIMB.2011.0015. (IF=0,622)

  3. de Mouzon J, Goossens V, Bhattacharya S, Castilla JA, Ferraretti AP, Korsak V, Kupka M, Nygren KG, Andersen AN; European IVF-Monitoring (EIM); Consortium for the European Society on Human Reproduction and Embryology (ESHRE). Assisted reproductive technology in Europe, 2007: results generated from European registers by ESHRE. Hum Reprod. 2012 Apr;27(4):954-66. doi: 10.1093/humrep/des023. (IF=4,670)

  4. Ferraretti AP, Goossens V, de Mouzon J, Bhattacharya S, Castilla JA, Korsak V, Kupka M, Nygren KG, Nyboe Andersen A; The European IVF-monitoring (EIM); Consortium, for the European Society of Human Reproduction and Embryology (ESHRE). Assisted reproductive technology in Europe, 2008: results generated from European registers by ESHRE. Hum Reprod. 2012 Sep;27(9):2571-84. (IF=4,670)

Updated 2022-02-22 11:01