Why does NCI need biobank?

Biobank consists of libraries of new generation, in which biomedical samples and health information of patients that were treated in NCI, are collected, stored and processed. We will accumulate large, well-classified collections of biological samples and health information of oncological patients, and researchers of the new generation will be able to use them, to search, find and receive information, intended for them for performing of high-level scientific researches.

Research areas

  • Creation, mastering and transfer for clinical practice of new freezing technologies (cryobiology researches, cell and tissue freezing technologies).
  • The search for molecular and genetic cancer markers (gene polymorphisms, gene expression tests in tumors of various localities), researches of carcinogenesis signalling paths.

Main projects

  1. Significance of polymorphism of oncogenetic human papillomaviruses types and some genes, causing tumor process in carcinogenesis (2014-2018, Head Ž. Gudlevičienė).
  2. Significance of polymorphism of oncogenic types of human papillomaviruses and genes, influencing some tumor processes to efficiency of oncological patient therapy (2013–2017, Heads Ž. Gudlevičienė, A. Stumbrytė).
  3. Reducing of the gap between Europe and Africa in the area of bio-banking and biomedical researches (2015–2018, Head Ž. Gudlevičienė).



  1. Dobrovolskienė N, Pašukonienė V, Darinskas A, Kraśko JA, Žilionytė K, Mlynska A, Gudlevičienė Ž, Mišeikytė-Kaubrienė E, Schijns V, Lubitz W, Kudela P, Strioga M. Tumor lysate-loaded Bacterial Ghosts as a tool for optimized production of therapeutic dendritic cell-based cancer vaccines. Vaccine. 2018; 36(29):4171-4180. doi: 10.1016/j.vaccine.2018.06.016.


  1. Baltruskeviciene E, Kazbariene B, Aleknavicius E, Krikstaponiene A, Venceviciene L, Suziedelis K, Stratilatovas E, Didziapetriene J. Changes of reduced glutathione and glutathione S-transferase levels in colorectal cancer patients undergoing treatment. Tumori. 2017:0.


  1. Baltruškevičienė E, Kazbarienė B, Badaras R, Bagdonaitė L, Krikštaponienė A, Zdanavičius L, Aleknavičius E, Didžiapetrienė J. Glutathione and glutathione S-transferase levels in patients with liver metastases of colorectal cancer and other hepatic disorders. Turk J Gastroenterol. 2016; 27(4):336–41.

  2. Kundrotas G, Gasperskaja E, Slapsyte G, Gudleviciene Z, Krasko J, Stumbryte A, Liudkeviciene R. Identity, proliferation capacity, genomic stability and novel senescence markers of mesenchymal stem cells isolated from low volume of human bone marrow. Oncotarget. 2016; 7(10):10788-802. doi: 10.18632/oncotarget.7456.


  1. Gudleviciene Z, Kanopiene D, Stumbryte A, Bausyte R, Kirvelaitis E, Simanaviciene V, Zvirbliene A. Studies on the integration of human papillomavirus type 16 in cervical cancer cells. Open Med 2015; 10(1): 1–7. DOI 10.1515/med-2015-0001.

  2. Gudleviciene Z, Kundrotas G, Liudkeviciene R, Rascon J, M Jurga. Quick and effective method of bone marrow mesenchymal stem cell extraction. Open Med 2015; 10(1): 44-49. DOI 10.1515/med-2015-0008.

  3. Simanaviciene V, Popendikyte V, Gudleviciene Z, Zvirbliene A. Different DNA methylation pattern of HPV16, HPV18 and HPV51 genomes in asymptomatic HPV infection as compared to cervical neoplasia. Virology. 2015; 484: 227-33. doi: 10.1016/j.virol.2015.06.008.

  4. A comparison of methylation levels in HPV16, HPV18 and HPV51 genomes in asymptomatic HPV infection and cervical neoplasia By: Simanaviciene, V.; Popendikyte, V.; Gudleviciene, Z.; et al. Conference: 31st Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE) Location: Lisbon, Portugal. Date: JUN 14-17, 2015. Sponsor(s): European Soc Human Reprod & Embryol. Hum Reproduc Volume: 30 Supplement: 1 Pages: 324-325.

  5. Gudlevičienė Ž, Stumbrytė A, Juknė G, Simanavičienė V, Žvirblienė A. Distribution of human papillomavirus type 16 variants in Lithuanian women with cervical cancer. Medicina (Kaunas). 2015;51(6):328-35. doi: 10.1016/j.medici.2015.11.005.

  6. Kristina Bielskienė, Lida Bagdonienė, Julija Mozūraitienė, Birutė Kazbarienė, Ernestas Janulionis. E3 ubiquitin ligases as drug targets and prognostic biomarkers in melanoma. Medicina (Kaunas) 2015; 51(1): 1-9.

  7. Julija Mozūraitienė, Kristina Bielskienė, Vydmantas Atkočius, Danutė Labeikytė. Molecular alterations in signal pathways of melanoma and new personalized treatment strategies: Targeting of Notch. Medicina (Kaunas) 2015; 51(3): 133-145.

Updated 2019-03-25 13:30