Vienintelė specializuota, Europos vėžio institutų organizacijos
akredituota onkologijos įstaiga Lietuvoje

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Laboratory of Molecular Oncology

  • ▶ Better understanding of cancer biology to find molecular biomarkers for better cancer patients’ diagnosis, prognosis and treatment decisions
    ▶ Better understanding of cancer biology to suggest more efficient treatment strategies
    ▶ Translation of cancer biology knowledge into specific models of treatment individualization for cancer patients

  • ▶ DNA, RNA, protein extraction from tumor and non-tumor tissues, blood, serum, bronchial washes, FFPE blocks, lymphocytes, cell cultures
    ▶ DNA and RNA quality and quantity analysis using, Bioanalyser (RIN), capillary electrophoresis (QIAxcel)
    ▶ RNA amplification, evaluation of linearity of amplification
    ▶ Gene expression analysis by qPCR, Western blots
    ▶ Gene mutation analysis using PCR, RFLP-PCR, Pyrosequencing
    ▶ Global transcriptomics using DNA microarrays
    ▶ 2D and 3D cell cultures
    ▶ Cell reprogramming, iPSC
    ▶ Genome editing using CRISPR/Cas tools
    ▶ Bioinformatics

  •     "Development of more efficient strategies of anticancer therapy based on the knowledge of tumour biology and molecular processes during the treatment of cancer patients"

  • ▶ Cellular response to ionizing radiation
    ▶ Tumor microenvironment
    ▶ Plasticity of cancer cells
    ▶ Molecular markers for cancer diagnosis, prognosis, prediction and evaluation of treatment eficacy

  • ▶ Kestutis Suziedelis; Dr. PhD – head of the Laboratory;  chief researcher
    ▶ Ryte Rynkeviciene; Dr, research fellow
    ▶ Diana Schveigert; Dr. research fellow
    ▶ Egle Strainiene; research fellow
    ▶ Vaidotas Stankevičius; junior research fellow
    ▶ Julija Fadejeva; junior research fellow
    ▶ Linas Kunigenas; technician
    ▶ Naneta Pajuodyte; technician

  • ▶ Investigation of the plasticity of cancer cells using modern cell culture models. Recent studies indicate that stem-like cancer cells are affecting/ causing tumor resistance to various therapies. The aim of this project is to investigate the role of plasticity of cancer cells in response to ionizing radiation of cancer cells
    ▶ DNA damage repair system as a source for cancer biomarkers. The aim of this project is to evaluate the importance of mutations and expression levels of different DNA damage repair system genes and miRNA to predict the post-operative treatment of cancer patients
    ▶ Development of more advanced drug targeted radiotherapy. Application of modern cell culture models and fractionated dose irradiation reveal potential targets for more efficient radiotherapy. Biological samples of radiotherapy treated patients and genome editing technologies using CRISPR/Cas tools are employed to validate selected molecular targets