Genetinės diagnostikos laboratorija

Svarbiausios publikacijos žurnaluose, įrašytuose į mokslinės informacijos instituto (Web of Science Clarivate Analytics) sąrašą:


  1. M. de With, A. Sadlon, E Cecchin, V. Haufroid, F. Thomas, M. Joerger, R. H. N. Van Schaik, R. H. J. Mathijssen, C. R. Largiader. Implementation of dihidropyrimidine dehydrogenase deficiency testing in Europe. ESMO Open. 2023 Mar 27;8(2):101197. doi: 10.1016/j.esmoop.2023.101197 (darbo grupės narė R.Sabaliauskaitė).
  2. Drazdauskiene U, Kapustina Z, Medziune J, Dubovskaja V, Sabaliauskaite R, Jarmalaite S, Lubys A. Fusion sequencing via terminator-assisted synthesis (FTAS-seq) reveals novel TMPRSS2 fusion partners in prostate cancer. DOI: 10.1002/1878-0261.13428
  3. Vaicekauskaite I, Dabkeviciene D, Simiene J, Zilovic D, Ciurliene R, Jarmalaite S, Sabaliauskaite R. ARID1A, NOTCH and Wnt signature in gynaecological tumours. Int J Mol Sci. 2023 Mar 19;24(6):5854. doi: 10.3390/ijms24065854.
  4. Januskevicius T, Sabaliauskaite R, Dabkeviciene D, Vaicekauskaite I, Kulikiene I, Sestokaite A, Vidrinskaite A, Bakavicius A, Jankevicius F, Ulys A, Jarmalaite S. Urinary DNA as a tool for germline and somatic mutation detection in castration-resistant prostate cancer patients. Biomedicines. 2023 Mar 2;11(3):761. doi: 10.3390/biomedicines11030761.
  5. Zilovic D, Vaicekauskaite I, Ciurliene R, Sabaliauskaite R, Jarmalaite S. Uterine Cavity Lavage Mutation Analysis in Lithuanian Ovarian Cancer Patients. 2023 Jan 30;15(3):868. doi: 10.3390/cancers15030868.
  6. Matulevicius A, Zukauskaite K, Gineikaite R, Dasavicius D, Trakymas M, Naruseviciute I, Usinskienė J, Ulys A, Jankevicius F, Jarmalaite S. Combination of DNA methylatio biomarkers with multiparametric magnetic resonance and ultrasound imaging fusion biopsy to detect the local spread of prostate cancer.
  7. Zilovic D, Ciurliene R, Sidlovska E, Vaicekauskaite I, Sabaliauskaite R, Jarmalaite S. Synchronous endomatrial and ovarian cancer. A case repost anr review of the literature. WJCC
  8. Snipaitiene K, Zablockiene B, Sabaliauskaite R, Zukauskaite K, Matulyte E, Smalinskaite T, Paulauskas M, Zablockis R, Lopeta M, Gagilas J, Puriene A, Jancoriene L, Jarmalaite E. SARS-CoV-2 RT-qPCR Ct values in saliva and nasopharyngeal swab samples for disease severity prediction. Journal of oral microbiology. 2023, Vol 15.
  9. Sestokaite A, Sabaliauskaite R, Gedvilaite V, Cicenas S, Jarmalaite S. Surveillance of cfDNA hot spot mutations in NSCLC patients during disease progression. Int J Mol Sci. 2023 Apr 9;24(8):6958. doi: 10.3390/ijms24086958.


  1. Vaicekauskaitė I, Sabaliauskaitė R, Lazutka JR, Jarmalaitė S. The Emerging Role of Chromatin Remodeling Complexes in Ovarian Cancer. International Journal of Molecular Sciences, 2022; 23(22):13670.;
  2. Žalimas A, Kubiliūtė R, Žukauskaitė K, Sabaliauskaitė R, Trakymas M, Letautienė S, Mišeikytė-Kaubrienė E, Ušinskienė J, Ulys A, Jarmalaitė J. Urine molecular biomarkers for detection and follow-up of small renal masses. Int. J. Mol. Sci. 2022, 23, 16110.;
  3. Norkeviciene A, Gocentiene R, Sestokaite A, Sabaliauskaite R, Dabkeviciene D, Jarmalaite S, Bulotiene G. A Systematic Review of Candidate Genes for Major Depression. Medicina (Kaunas). 2022 Feb 14;58(2):285. doi: 10.3390/medicina58020285. PMID: 35208605; PMCID: PMC8875554;
  4. Matulevicius A, Bakavicius A, Ulys A, Trakymas M, Usinskiene J, Naruseviciute I, Sabaliauskaite R, Zukauskaite K, Jarmalaite S, Jankevicius F. Multiparametric MRI fusion-guided prostate biopsy for detection of clinically significant prostate cancer eliminates the systemic prostate biopsy. Applied Sciences. 2022, 12(19), 10151.;
  5. Klimaite R, Kazokaite M, Kondrotiene A, Dauksiene D, Sabaliauskaite R, Zukauskaite K, Zilaitiene B, Jarmalaite S, Dauksa A. The Role of TSHR, PTEN and RASSF1A Promoters’ Methylation Status for Non-Invasive Detection of Papillary Thyroid Carcinoma. Journal of Clinical Medicine. 2022; 11(16):4917.;
  6. Sadzeviciene I, Snipaitiene K, Scesnaite-Jerdiakova A, Daniunaite K, Sabaliauskaite R, Laurinaviciene A, Drobniene M, Ostapenko V, Jarmalaite S. Analysis of Intrinsic Breast Cancer Subtypes: The Clinical Utility of Epigenetic Biomarkers and TP53 Mutation Status in Triple-Negative Cases. Int J Mol Sci. 2022 Dec 6;23(23):15429. doi: 10.3390/ijms232315429. PMID: 36499753 Free PMC article;
  7. Snipaitiene K, Bakavicius A, Lazutka JR, Ulys A, Jankevicius F, Jarmalaite S.Urinary microRNAs can predict response to abiraterone acetate in castration resistant prostate cancer: A pilot study. Prostate. 2022 Mar;82(4):475-482. doi: 10.1002/pros.24293. Epub 2021 Dec 30. PMID: 34970742;
  8. Rovas A, Puriene A, Snipaitiene K, Punceviciene E, Buragaite-Staponkiene B, Matuleviciute R, Butrimiene I, Jarmalaite S. Gingival crevicular fluid microRNA associations with periodontitis. J Oral Sci. 2022 Jan 19;64(1):11-16. doi: 10.2334/josnusd.21-0282. Epub 2021 Oct 25.  PMID: 34690249 Free article.


  1. Snipaitiene K, Bakavicius A, Lazutka JR, Ulys A, Jankevicius F, Jarmalaite S. Urinary microRNAs can predict response to abiraterone acetate in castration resistant prostate cancer: A pilot study. Prostate. 2021 Dec 30.doi: 10.1002/pros.24293;
  2. Punceviciene E, Gaizevska J, Sabaliauskaite R, Venceviciene L, Puriene A, Vitkus D, Jarmalaite S, Butrimiene I. Vitamin D and VDR Gene Polymorphisms Association with Rheumatoid Arthritis in Lithuanian Population. Medicina. 2021;
  3. Kubiliute R, Zukauskaite K, Zalimas A, Ulys A, Sabaliauskaite A, Bakavicius A, Zelvys A, Jankevicius F, Jarmalaite S. Clinical significance of novel DNA methylation biomarkers for renal clear cell carcinoma. Journal of Cancer Research and Clinical Oncology 2021 Oct 23. Online ahead of print.;
  4. D. Žilovič, R. Čiurlienė, R. Sabaliauskaitė, S. Jarmalaitė. Future screening prospects for ovarian cancer. Cancer. 2021, 13 (15):3840.;
  5. Kubiliute R, Zalimas A, Bakavicius A, Ulys A, Jankevicius F, Jarmalaite S. Clinical significance of ADAMTS19, BMP7, SIM1 and SFRP1 promoter methylation in renal clear cell carcinoma. OncoTargets and Therapy 2021 Oct 5;14:4979-4990.;
  6. Kubiliute R, Jarmalaite S. Epigenetic Biomarkers of Renal Cell Carcinoma for Liquid Biopsy Tests. International Journal of Molecular Sciences 2021 Aug 17;22(16):8846. doi10.3390/ijms22168846;
  7. Kubiliute R, Januskeviciene I, Urbanaviciute R, Daniunaite K, Drobniene M, Ostapenko V, Daugelavicius R, Jarmalaite S. Nongenotoxic ABCB1 activator tetraphenylphosphonium can contribute to doxorubicin resistance in MX-1 breast cancer cell line. Scientific Reports 2021;11(1):6556.;
  8. Daniunaite K, Bakavicius A, Zukauskaite K, Rauluseviciute I, Lazutka JR, Ulys A, Jankevicius F, Jarmalaite S. Promoter Methylation of PRKCB, ADAMTS12, and NAALAD2 Is Specific to Prostate Cancer and Predicts Biochemical Disease Recurrence. International Journal of Molecular Sciences. 2021;
  9. Lachej N, Dabkeviciene D, Simiene J, Sabaliauskaite R, Jonusiene V, Brasiunas V, Sasnauskiene A, Vaicekauskaite I, Brasiuniene B, Kanopiene D, Suziedelis K, Didziapetriene J. Components of NOTCH signaling for uterine cencer patiens prognosis. Journal of Oncology.;
  10. Rovas A, Puriene A, Snipaitiene K, Punceviciene E, Buragaite-Staponkiene B, Matuleviciute R, Butrimiene I, Jarmalaite S. Analysis of periodontitis-associated miRNAs in gingival tissue, gingival crevicular fluid, saliva and blood plasma. Arch Oral Biol. 2021;126:105125. doi: 10.1016/j.archoralbio.2021.105125;
  11. Rovas A, Puriene A, Punceviciene E, Butrimiene I, Stuopelyte K, Jarmalaite S. Associations of periodontal status in periodontitis and rheumatoid arthritis patients. J Periodontal Implant Sci. 2021;51(2):124-134. doi: 10.5051/jpis.2006060303;
  12. Punceviciene E, Rovas A, Puriene A, Stuopelyte K, Vitkus D, Jarmalaite S, Butrimiene I. Investigating the relationship between the severity of periodontitis and rheumatoid arthritis: a cross-sectional study. Clin Rheumatol. 2021;40(8):3153-3160. doi: 10.1007/s10067-021-05661-3.


  1. Daniunaite K, Sestokaite A, Kubiliute R, Stuopelyte K, Kettunen E, Husgafvel-Pursiainen K,  Jarmalaite S. Frequent DNA methylation changes in cancerous and noncancerous lung tissues from smokers with non-small cell lung cancer.  Mutagenesis. 2020; geaa022:1-7. (IF=3,379)
  2. Stuopelyte K, Sabaliauskaite R, Bakavicius A, Haflidadóttir BS, Visakorpi T, Väänänen RM, Patel C, Danila DC, Lilja H, Lazutka JR, Ulys A, Jankevicius F, Jarmalaite S. Analysis of AR-FL and AR-V1 in Whole Blood of Patients with Castration Resistant Prostate Cancer as a Tool for Predicting Response to Abiraterone Acetate. J Urol. 2020; 204(1):71-78 . (IF=5,925)
  3. Bakavičius A, Drevinskaitė M, Daniūnaitė K, Barisienė M, Jarmalaitė S, Jankevičius F.The Impact of Prostate Cancer Upgrading and Upstaging on Biochemical Recurrence and Cancer-Specific Survival. Medicina (Kaunas). 2020; 56(2):1-11. (IF=1,205)
  4. Sadzevičienė I, Liaugaudienė O, Besusparis J, Asadauskienė J, Kulikienė I, Brasiūnienė B, Sabaliauskaitė R, Jarmalaitė S. Recurrent Germline BRCA2 Gene Mutation in Lithuanian Family. Medicina 2020, 56(3), 119:1-9; doi: 10.3390/medicina56030119 (IF=1,205)


  1. Bakavicius A, Daniunaite K, Zukauskaite K, Barisiene M, Jarmalaite S, Jankevicius F. Urinary DNA methylation biomarkers for prediction of prostate cancer upgrading and upstaging. Clin Epigenetics. 2019 Aug 5;11(1):115. doi: 10.1186/s13148-019-0716-z. (IF=5,496)
  2. Maleckaite R, Zalimas A, Bakavicius A, Jankevicius F, Jarmalaite S, Daniunaite K. DNA methylation of metallothionein genes is associated with the clinical features of renal cell carcinoma. Oncol Rep. 2019 Jun;41(6):3535-3544. doi: 10.3892/or.2019.7109. (IF=3,041)


  1. Demidenko R, Daniunaite K, Bakavicius A, Sabaliauskaite R, Skeberdyte A, Petroska D, Laurinavicius A, Jankevicius F, Lazutka JR, Jarmalaite S. Decreased expression of MT1E is a potential biomarker of prostate cancer progression. Oncotarget. 2017 Jun 27;8(37):61709-61718. doi: 10.18632/oncotarget.18683. (IF=5,168)
  2. Gyvyte U, Juzenas S, Salteniene V, Kupcinskas J, Poskiene L, Kucinskas L, Jarmalaite S, Stuopelyte K, Hemmrich-Stanisak G, Hübenthal M, Franke A, Pangonyte D, Lesauskaite V, Kupcinskas L, Skieceviciene J. MiRNA profiling of gastrointestinal stromal tumors by next-generation sequencing. Oncotarget. 2017 Jun 6;8(23):37225-37238. doi: 10.18632/oncotarget.16664. (IF=5,168)
  3. Kettunen E, Hernandez-Vargas H, Cros MP, Durand G, Le Calvez-Kelm F, Stuopelytė K, Jarmalaitė S, Salmenkivi K, Anttila S, Wolff H, Herceg Z, Husgafvel-Pursiainen K. Asbestos-associated genome-wide DNA methylation changes in lung cancer. Int J Cancer. 2017 Nov 15;141(10):2014-2029. doi: 10.1002/ijc.30897. (IF=6,513)


  1. Stuopelyte K, Daniunaite K, Bakavicius A, Lazutka JR, Jankevicius F, Jarmalaite S. The utility of urine-circulating miRNAs for detection of prostate cancer. Br J Cancer. 2016 Sep 6;115(6):707-15. doi: 10.1038/bjc.2016.233. (IF=6,176)
  2. Kubiliūtė R, Šulskytė I, Daniūnaitė K, Daugelavičius R, Jarmalaitė S. Molecular features of doxorubicin-resistance development in colorectal cancer CX-1 cell line. Medicina (Kaunas). 2016;52(5):298-306. doi: 10.1016/j.medici.2016.09.003. (IF=0,802)
  3. Stuopelytė K, Daniūnaitė K, Jankevičius F, Jarmalaitė S. Detection of miRNAs in urine of prostate cancer patients. Medicina (Kaunas). 2016;52(2):116-24. doi: 10.1016/j.medici.2016.02.007. (IF=0,802)

Atnaujinta 2023-08-29 09:28