The only specialized oncology institution in Lithuania accredited by Organisation of European Cancer Institutes

Genetic Diagnostic Centre

Clinical and scientific work Genetic Diagnostic Centre – gene mutation, changes in gene expression, epigenetic damages detection for cancer diagnosis, selection of the treatment, and disease prediction.

 

In Genetic Diagnostics Centre we have installed the newest genetic analysis techniques: a new generation sequencing and real-time PCR methods. New generation sequencing method allows multiple genes sequencing for total gene mutations and/or gene expression profile per single run. Real-time PCR method enables accurate, sensitive and rapid identification of selected mutations in genes that are important targets for therapy selection and prognosis of the course of the disease. Also, the Centre has developed the latest research methods allowing detection of cell-free cancer nucleotides (methylated DNA and/or microRNAs) circulating in bodily fluids and circulating tumour cells.

  • ▶ BRCA1, BRCA2, KRAS, NRAS, BRAF, EGFR, DPYD of the most common gene mutations detection
    ▶ EML4-ALK, TMPRSS2-ERG fused transcripts detection
    ▶ UGT1A1 polymorphism detection
    ▶ Hereditary cancers determination, based on a detailed analysis of the new-generation sequencing
    ▶ Circulating tumour cell and cancer nucleic acid detection in blood and urine

      • ▶ Molecular tools for prostate cancer long-term monitoring and treatment individualisation (LMT project SEN-9/2016)
        ▶ Kidney cancer molecular markers analysis in patient urine (Novartis Pharma Services charter study, supported by MITA)